A Guide to AMPK Activators
AMPK is deemed as the regulator that maintains cellular energy homeostasis that is the foundation for proper functioning of the body. When it comes to AMPK in mammals, this works by regulating energy balance both on cellular level through sensing ATP/AMP and ATP/ADP ratio levels and at the same time, whole body by means of responding to the hormones and the brain.
In the body, the most important energy molecule that is present is ATP. In essence, this is the starting point of cellular function. Because energy is being used by cells, ATP is breaking down into ADP which has less potential for energy. ADP is then broken down to AMP which has contains the least energy potential among all 3. In reality, this is where AMPK is used; it senses the ratios of ATP/ADP/AMP and it tells the body if it requires more ADP so by that, it will be able to maintain optimal functions.
AMPK work on different processes via different mechanisms. This makes sense since AMPK is the master regulator of all functioning cells. The impact of AMPK activation in our body will depend on a complicated balance of both factors as well as signaling pathways. Even so, there are some accepted benefits of increased AMPK activation including:
Anti aging – AMPK activation is gradually declining as we are aging. Experts actually think that AMPK is one of the contributing factors of aging. It is promoting cellular renewal and also, the production of new mitochondria.
Anti inflammation – inflammation decreases the level of AMPK activation in the body but what’s interesting is that, AMPK is used as well to decrease inflammation.
Anti diabetic – the truth is, AMPK is becoming more and more understood when it comes to its role in diabetes treatment mainly because of the ability it has in enhancing insulin sensitivity.
There are so many herbal products/constituents as well as nutritional products that have been proven to be an effective AMPK activator and some of it include:
Number 1. AICAR – this is AMP’s analog which is required for cellular use and storage similar to ATP. Because it is AMP’s analog, AICAR has the capability of stimulating AMPK’s activity directly which can actually boost muscle performance.
Number 2. ALA – ALA or in this case, Alpha Lipoic Acid is not just an effective antioxidant but also, a powerful AMPK activator. This has been uncovered to have anti obesity effect and can increase insulin sensitivity.
Number 3. Green tea extract – this helps in activating upstream kinase which then helps in activating AMPK.
Number 4. Berberine – not just that it is an AMPK activator, it has berberine containing metformin which is great for anti-diabetes.